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GNAL Rabbit pAb
GNAL Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P38405 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Chicken, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44308 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GNAL |
| Epitope Specificity | 21-130/381 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (e.g., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. More recent evidence, however, has established an important regulatory role for the beta gamma subunits (6-8). The Gs subfamily of G alpha subunits includes two closely related proteins, Ga s and Ga olf, which respectively stimulate adenylate cyclase and mediate response to olfactory stimuli (9). |
| Gene ID | 2774 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(olf) subunit alpha, 3.6.5.-, Adenylate cyclase-stimulating G alpha protein, olfactory type, GNAL {ECO:0000303|PubMed:23222958, ECO:0000312|HGNC:HGNC:4388} |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GNAL {ECO:0000303|PubMed:23222958, ECO:0000312|HGNC:HGNC:4388} |
|---|---|
| Function | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein- coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8CGK7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8CGK7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8CGK7}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000250|UniProtKB:P04896} |
| Tissue Location | Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen (PubMed:8243272). Trace amounts where seen in kidney, adrenal gland and liver (PubMed:8243272). Found to be expressed in all the insulinomas examined (PubMed:8243272). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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