癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Gα olf Polyclonal Antibody
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- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | P38405 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44308 Da |
| Gene ID | 2774 |
|---|---|
| Other Names | GNAL; Guanine nucleotide-binding protein G(olf) subunit alpha; Adenylate cyclase-stimulating G alpha protein; olfactory type |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. IHC-P~~1:50~200 IF~~1:50~200 ICC~~N/A E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GNAL {ECO:0000303|PubMed:23222958, ECO:0000312|HGNC:HGNC:4388} |
|---|---|
| Function | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein- coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8CGK7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8CGK7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8CGK7}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000250|UniProtKB:P04896} |
| Tissue Location | Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen (PubMed:8243272). Trace amounts where seen in kidney, adrenal gland and liver (PubMed:8243272). Found to be expressed in all the insulinomas examined (PubMed:8243272). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
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