DNER Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF, E
Primary Accession	Q8NFT8
Predicted	Human, Mouse, Rat, Dog, Sheep
Host	Rabbit
Clonality	Polyclonal
Calculated MW	75 KDa
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human DNER
Epitope Specificity	185-300/737
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION	Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.
SIMILARITY	Contains 10 EGF-like domains. Contains 1 follistatin-like domain.
SUBUNIT	Interacts with AP1G1. Interacts with NOTCH1.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.

Additional Information
Other Names	Delta and Notch-like epidermal growth factor-related receptor, DNER, BET
Target/Specificity	Expressed in brain, spinal cord and adrenal gland.
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.