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KCNH3 Rabbit pAb
KCNH3 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9ULD8 |
| Predicted | Human, Mouse, Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117129 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCNH3 |
| Epitope Specificity | 331-430/1083 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multipass membrane protein. |
| SIMILARITY | Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain. |
| SUBUNIT | The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH3 is a pore forming (alpha) subunit of voltage-gated potassium channel. It elicits an outward current with fast inactivation. |
| Gene ID | 23416 |
|---|---|
| Other Names | Voltage-gated inwardly rectifying potassium channel KCNH3, Brain-specific eag-like channel 1, BEC1, Ether-a-go-go-like potassium channel 2, ELK channel 2, ELK2, Potassium voltage-gated channel subfamily H member 3, Voltage-gated potassium channel subunit Kv12.2, KCNH3 (HGNC:6252), KIAA1282 |
| Target/Specificity | Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | KCNH3 (HGNC:6252) |
|---|---|
| Synonyms | KIAA1282 |
| Function | Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel (PubMed:10455180). Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism (PubMed:10455180). Exhibits a rapid recovery from inactivation (PubMed:10455180). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9WVJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WVJ0} Note=Expression on the cell membrane requires at least one of the three glycosylation sites to carry a sugar chain irrespective of their positions. {ECO:0000250|UniProtKB:Q9WVJ0} |
| Tissue Location | Detected only in brain, in particular in the telencephalon (PubMed:10455180). Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus (PubMed:10455180) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH3 is a pore forming (alpha) subunit of voltage-gated potassium channel. It elicits an outward current with fast inactivation.
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Cat# AP56452
