癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MRFAP1L1 Rabbit pAb
MRFAP1L1 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96HT8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14808 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MRFAP1L1 |
| Epitope Specificity | 31-100/127 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane |
| SIMILARITY | Belongs to the MORF4 family-associated protein family. |
| SUBUNIT | Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. MORF4 family-associated protein 1 (MRFAP1), also known as GAM14 or PGR1, is a 127 amino acid member of the MORF4 family-associated protein family. Localized to nucleus and cytoplasm, MRFAP1 colocalizes with MORF4L1 to the cell nuclei. Its association with MORF4L1 and Rb1 suggests that MRFAP1 may play a role in transcription regulation. The gene encoding human MRFAP1 maps to chromosome 4p16.1. |
| Gene ID | 114932 |
|---|---|
| Other Names | MORF4 family-associated protein 1-like 1, MRFAP1L1 |
| Target/Specificity | Expressed ubiquitously but at low levels.Shows a strong expression in the erythrocytes. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | MRFAP1L1 |
|---|
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. MORF4 family-associated protein 1 (MRFAP1), also known as GAM14 or PGR1, is a 127 amino acid member of the MORF4 family-associated protein family. Localized to nucleus and cytoplasm, MRFAP1 colocalizes with MORF4L1 to the cell nuclei. Its association with MORF4L1 and Rb1 suggests that MRFAP1 may play a role in transcription regulation. The gene encoding human MRFAP1 maps to chromosome 4p16.1.
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