NPTN Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q9Y639
Reactivity	Human
Predicted	Rat, Pig, Dog, Mouse, Chicken, Horse, Sheep
Host	Rabbit
Clonality	Polyclonal
Calculated MW	44387 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human NPTN
Epitope Specificity	51-150/298
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION	Cell membrane; Single-pass type I membrane protein (Potential). Note=Enriched at postsynaptic density (By similarity).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

Additional Information
Gene ID	27020
Other Names	Neuroplastin, Stromal cell-derived receptor 1, SDR-1, NPTN, SDFR1, SDR1
Dilution	WB=1:500-2000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	NPTN
Synonyms	SDFR1, SDR1
Function	Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (By similarity). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (By similarity). May play a role in synaptic plasticity (By similarity). Promotes localization of XKR8 at the cell membrane (PubMed:27503893).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:P97300}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:P97300}
Tissue Location	Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level) {ECO:0000269\|PubMed:17196182, ECO:0000269\|Ref.1}