癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEPHS1 Rabbit pAb
SEPHS1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P49903 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Dog, Human, Rabbit, Chicken, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42911 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SEPHS1 |
| Epitope Specificity | 2-100/392 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010] |
| Gene ID | 22929 |
|---|---|
| Other Names | Zincore component SEPHS1, Selenide, water dikinase 1, 2.7.9.3, Selenium donor protein 1, Selenophosphate synthase 1, SEPHS1 {ECO:0000303|PubMed:40608935, ECO:0000312|HGNC:HGNC:19685} |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEPHS1 {ECO:0000303|PubMed:40608935, ECO:0000312|HGNC:HGNC:19685} |
|---|---|
| Function | Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA- binding sites across the genome, thereby controlling gene expression (PubMed:40608935). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (PubMed:40608935). Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability (PubMed:40608935). Plays an essential role in redox homeostasis (PubMed:31607477). May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP (PubMed:7665581). Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role (PubMed:15534230). Required for cardiac differentiation (By similarity). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm Note=The zincore complex binds to a highly conserved promoter motif (5'-CTTTAAR-3'). [Isoform 2]: Cytoplasm [Isoform 4]: Cytoplasm |
| Tissue Location | [Isoform 1]: Gradually expressed during the cell cycle until G2/M phase and then decreases [Isoform 3]: Gradually expressed during the cell cycle until S phase and then decreases. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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