癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SH3BGRL3 Rabbit pAb
SH3BGRL3 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H299 |
| Reactivity | Rat |
| Predicted | Human, Dog, Horse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 10438 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SH3BGRL3 |
| Epitope Specificity | 31-93//93 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
| SIMILARITY | Belongs to the SH3BGR family. Contains 1 glutaredoxin domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SH3BGRL3 (SH3 Domain Binding Glutamate Rich Protein Like 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL2. |
| Gene ID | 83442 |
|---|---|
| Other Names | SH3 domain-binding glutamic acid-rich-like protein 3, SH3 domain-binding protein 1, SH3BP-1, TNF inhibitory protein B1, TIP-B1, SH3BGRL3 |
| Target/Specificity | Ubiquitous. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | SH3BGRL3 |
|---|---|
| Function | Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed:34380438). |
| Cellular Location | Cytoplasm, cytosol. Cell projection, ruffle membrane. Nucleus |
| Tissue Location | Ubiquitous (PubMed:11404387, PubMed:11444877). Expressed in heart, kidney and liver (at protein level) (PubMed:11404387). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11404387). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SH3BGRL3 (SH3 Domain Binding Glutamate Rich Protein Like 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL2.
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