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Steroid sulfatase Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Steroid sulfatase Polyclonal Antibody AP58101
    Sample:
    A431(Human) Cell Lysate at 30 ug
    Hela(Human) Cell Lysate at 30 ug
    Jurkat(Human) Cell Lysate at 30 ug
    Primary: Anti- Steroid sulfatase (AP58101) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 62 kD
    Observed band size: 63 kD
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IHC-F, IF, E
Primary Accession P08842
Reactivity Rat, Pig, Dog, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 65492 Da
Physical State Liquid
Immunogen KLH conjugated synthetic peptide derived from human Steroid sulfatase
Epitope Specificity 51-150/583
Isotype IgG
Purity affinity purified by Protein A
Buffer 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION Endoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITY Belongs to the sulfatase family.
SUBUNIT Homodimer.
Post-translational modifications The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
DISEASE Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008].
Additional Information
Gene ID 412
Other Names Steryl-sulfatase, 3.1.6.2, Arylsulfatase C, ASC, Estrone sulfatase, Steroid sulfatase, Steryl-sulfate sulfohydrolase, STS, ARSC1
Dilution WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Format0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name STS
Synonyms ARSC1
Function Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
Cellular Location Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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