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ICAM5 Rabbit pAb
ICAM5 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9UMF0 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97116 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ICAM5 |
| Epitope Specificity | 501-600/924 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single-pass type I membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. |
| Gene ID | 7087 |
|---|---|
| Other Names | Intercellular adhesion molecule 5, ICAM-5, Telencephalin, ICAM5 (HGNC:5348) |
| Dilution | WB=1:500-2000,Flow-Cyt=0.2ug/test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ICAM5 (HGNC:5348) |
|---|---|
| Function | Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed:8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:10893271). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q60625}; Single-pass membrane protein. Cell projection. Cell projection, uropodium. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q60625}. Note=At uropodium and cell- cell contact sites creates homophilic adhesion |
| Tissue Location | Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Brain specific expression (PubMed:9828136). Within the brain, only expressed in regions derived from the telencephalon (PubMed:9828136). Highly expressed in the hippocampus and cerebral cortex, followed by the amygdala, caudate nucleus, occipital pole, frontal lobe, temporal lobe, and putamen (PubMed:9828136). Lower expressed in the corpus callosum, subthalamic nucleus, and thalamus (PubMed:9828136). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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