癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SRRM3 Rabbit pAb
SRRM3 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | A6NNA2 |
| Predicted | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65249 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SRRM3 |
| Epitope Specificity | 165-260/597 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Other Names | Serine/arginine repetitive matrix protein 3, SRRM3 |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SRRM3 |
|---|---|
| Function | RNA splicing factor that regulates inclusion of microexons in mRNA transcripts (PubMed:35858306, PubMed:36759540). Required for motor coordination. In cortical neurons, acts redundantly with SRRM4 and regulates many alternative splicing events, including inclusion of exon 4 into the transcriptional repressor REST transcript, leading to REST inactivation. REST inactivation de-represses potassium-chloride cotransporter 2/SLC12A5 expression, resulting in the switch in GABAergic neurotransmission from immature excitatory to inhibitory (By similarity). Regulates inclusion of a microexon in TBC1D24 in the brain cortex (By similarity). In pancreatic islets, mediates microexon inclusion and regulates glucose- or amino acid-stimulated insulin secretion, as well as glucagon secretion (PubMed:36759540). Regulates microexon inclusion in the developing retina, which is required for outer segment maintenance and vision (By similarity). |
| Tissue Location | Expressed in neural tissues and in pancreatic islet cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
