癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SRRM3 Antibody(Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | A6NNA2 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65249 Da |
| Antigen Region | 264-291 aa |
| Other Names | Serine/arginine repetitive matrix protein 3, SRRM3 |
|---|---|
| Target/Specificity | This SRRM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-291 amino acids from the Central region of human SRRM3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SRRM3 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SRRM3 |
|---|---|
| Function | RNA splicing factor that regulates inclusion of microexons in mRNA transcripts (PubMed:35858306, PubMed:36759540). Required for motor coordination. In cortical neurons, acts redundantly with SRRM4 and regulates many alternative splicing events, including inclusion of exon 4 into the transcriptional repressor REST transcript, leading to REST inactivation. REST inactivation de-represses potassium-chloride cotransporter 2/SLC12A5 expression, resulting in the switch in GABAergic neurotransmission from immature excitatory to inhibitory (By similarity). Regulates inclusion of a microexon in TBC1D24 in the brain cortex (By similarity). In pancreatic islets, mediates microexon inclusion and regulates glucose- or amino acid-stimulated insulin secretion, as well as glucagon secretion (PubMed:36759540). Regulates microexon inclusion in the developing retina, which is required for outer segment maintenance and vision (By similarity). |
| Tissue Location | Expressed in neural tissues and in pancreatic islet cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this protein remains unknown.
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¥ 1,250.00
Cat# AP19628c
