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RNF156 Rabbit pAb
RNF156 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O60291 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig, Dog, Rabbit, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60753 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RNF156 |
| Epitope Specificity | 201-300/552 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Cell membrane. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. |
| Gene ID | 23295 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MGRN1, 2.3.2.27, Mahogunin RING finger protein 1, RING finger protein 156, RING-type E3 ubiquitin transferase MGRN1, MGRN1 (HGNC:20254), KIAA0544, RNF156 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MGRN1 (HGNC:20254) |
|---|---|
| Synonyms | KIAA0544, RNF156 |
| Function | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H (PubMed:17229889, PubMed:19703557). Plays a role in the regulation of endosome-to-lysosome trafficking (PubMed:17229889). Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production (PubMed:19737927). Does not inhibit ADRB2-signaling (PubMed:19737927). Does not promote MC1R ubiquitination (PubMed:19737927). Acts also as a negative regulator of hedgehog signaling (By similarity). |
| Cellular Location | Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101 [Isoform 2]: Cytoplasm, cytosol. Nucleus Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli [Isoform 4]: Cytoplasm, cytosol. Cell membrane. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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