癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MGRN1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant MGRN1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | O60291 |
| Other Accession | NM_015246 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 30 |
| Calculated MW | 60753 Da |
| Gene ID | 23295 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MGRN1, 632-, Mahogunin RING finger protein 1, RING finger protein 156, MGRN1, KIAA0544, RNF156 |
| Target/Specificity | MGRN1 (NP_056061, 477 a.a. ~ 576 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MGRN1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. P?rez-Oliva AB, et al. J Biol Chem, 2009 Nov 13. PMID 19737927.Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Chakrabarti O, et al. Cell, 2009 Jun 12. PMID 19524515.Pigmentation-related genes and their implication in malignant melanoma susceptibility. Fernandez LP, et al. Exp Dermatol, 2009 Jul. PMID 19320733.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
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