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>   首页   >   产品   >   一抗   >   精选抗体   >   Anti-CBX6 Antibody   

Anti-CBX6 Antibody

Rabbit polyclonal antibody to CBX6

     
  • 1 - Anti-CBX6 Antibody AP61301
    Western blot analysis of CBX6 expression in HEK293T (A), HCT116 (B), mouse testis (C), rat kidney (D) whole cell lysates.
  • 2 - Anti-CBX6 Antibody AP61301
    Immunohistochemical analysis of CBX6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession O95503
Other Accession Q9DBY5
Reactivity Human, Mouse, Rat, Bovine, Drosophila
Host Rabbit
Clonality Polyclonal
Calculated MW 43898 Da
Additional Information
Gene ID 23466
Other Names Chromobox protein homolog 6
Target/Specificity Recognizes endogenous levels of CBX6 protein.
Dilution WB~~WB (1/500 - 1/1000), IHC (1/50 - 1/200)
IHC~~WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CBX6
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3- independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).
Cellular Location Nucleus. Chromosome. Note=Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CBX6. The exact sequence is proprietary.

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