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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Topo IIα (phospho Ser1525) Polyclonal Antibody   

Topo IIα (phospho Ser1525) Polyclonal Antibody

     
  • 1 - Topo IIα (phospho Ser1525) Polyclonal Antibody AP67768
    Western blot analysis of 293T 3T3 COLO using p-Topo IIα (S1525) antibody. Antibody was diluted at 1:1000
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession P11388
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 174385 Da
Additional Information
Gene ID 7153
Other Names TOP2A; TOP2; DNA topoisomerase 2-alpha; DNA topoisomerase II; alpha isozyme
Dilution WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
IHC-P~~N/A
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name TOP2A
Synonyms TOP2
Function Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).
Cellular Location Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus
Tissue Location Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).

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