癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cytokeratin 16 Polyclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | P08779 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51268 Da |
| Gene ID | 3868 |
|---|---|
| Other Names | KRT16; KRT16A; Keratin; type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. IHC-P~~1:50~200 IF~~1:50~200 ICC~~N/A E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT16 (HGNC:6423) |
|---|---|
| Synonyms | KRT16A |
| Function | Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin intermediate filament networks that contribute to cytoskeletal resilience of palm, sole, nail bed and oral mucosa (PubMed:7539673, PubMed:8595410). Regulates epidermal innate immunity and inflammatory signaling in response to barrier disruption. Required for normal palmoplantar epidermal differentiation and nail unit structure (By similarity). |
| Tissue Location | Expressed in the corneal epithelium (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
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