癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MRP2 Polyclonal Antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q92887 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 174207 Da |
| Gene ID | 1244 |
|---|---|
| Other Names | ABCC2; CMOAT; CMOAT1; CMRP; MRP2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ABCC2 {ECO:0000303|PubMed:31704245, ECO:0000312|HGNC:HGNC:53} |
|---|---|
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells where it mediates hepatobiliary and renal excretion of conjugated substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456, PubMed:29175180, PubMed:30959153, PubMed:31704245). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:9355767, PubMed:10421658). Mediates the efflux of steroid glucuronates from intestine and liver into the intestinal lumen. Shares substrate specificity with MRP3 but displays lower affinity and higher transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (PubMed:29175180, PubMed:30959153, PubMed:31704245). Transports glutathione conjugate leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:11500505). Displays selective transporter activity toward sulfated conjugates, transports sulfated bile salts such as taurolithocholate sulfate but is inactive toward androgen sulfates (PubMed:16332456, PubMed:39993711). Transports various xenobiotics including anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (PubMed:10220572, PubMed:11500505, PubMed:12441801). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical membrane of enterocytes |
| Tissue Location | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine (PubMed:28408210). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
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