癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NMUR1 Polyclonal Antibody
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- 背景知识
Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | Q9HB89 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47351 Da |
| Gene ID | 10316 |
|---|---|
| Other Names | NMUR1; GPR66; Neuromedin-U receptor 1; NMU-R1; G-protein coupled receptor 66; G-protein coupled receptor FM-3 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. IF~~1:50~200 ICC~~N/A E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NMUR1 (HGNC:4518) |
|---|---|
| Function | G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10899166, PubMed:15635449, PubMed:35440625). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor- dependent manner (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:15331768). GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5- bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum (PubMed:10899166, PubMed:15331768). Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation (PubMed:15331768). In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (By similarity). Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
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