癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STK35 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TDR2 |
| Other Accession | Q80ZW0 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58051 Da |
| Antigen Region | 374-404 aa |
| Gene ID | 140901 |
|---|---|
| Other Names | Serine/threonine-protein kinase 35, CLP-36-interacting kinase 1, CLIK-1, PDLIM1-interacting kinase 1, Serine/threonine-protein kinase 35 L1, STK35, CLIK1, PDIK1, STK35L1 |
| Target/Specificity | This STK35 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-404 amino acids from the Central region of human STK35. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STK35 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STK35 |
|---|---|
| Synonyms | CLIK1, PDIK1, STK35L1 |
| Cellular Location | Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. |
| Tissue Location | Expressed in testis. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
STK35 can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded kinase may be a regulator of actin stress fibers in nonmuscle cells. This protein has also been found in the nucleus.
REFERENCES
Vallenius, T., et al., J. Cell. Sci. 115 (Pt 10), 2067-2073 (2002).
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