MYCN Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application ![]()
| WB, IHC-P, E |
---|---|
Primary Accession | P04198 |
Other Accession | Q63379, P03966 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49561 Da |
Antigen Region | 322-351 aa |
Gene ID | 4613 |
---|---|
Other Names | N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC |
Target/Specificity | This MYCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human MYCN. |
Dilution | WB~~1:1000 IHC-P~~1:100 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MYCN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYCN |
---|---|
Synonyms | BHLHE37, NMYC |
Function | Positively regulates the transcription of MYCNOS in neuroblastoma cells. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level) |
For Research Use Only. Not For Use In Diagnostic Procedures.

Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MYCN is a member of the MYC family and a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of its gene is associated with a variety of tumors, most notably neuroblastomas.
REFERENCES
Combaret,V., Pediatr Blood Cancer 53 (3), 329-331 (2009)
Alvarez-Rodriguez,R., J. Cell. Sci. 122 (PT 5), 595-599 (2009)
Jacobs,J.F., BMC Cancer 9, 239 (2009)

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