癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
n-Myc Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P04198 |
| Other Accession | P04198 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49561 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human n-Myc |
| Epitope Specificity | 1-100/464 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 basic helix-loop-helix (bHLH) domain. |
| SUBUNIT | Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. |
| DISEASE | Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses. Defects in MYCN are the cause of Feingold syndrome type 1 (FGLDS1) [MIM:164280]. A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]. |
| Gene ID | 4613 |
|---|---|
| Other Names | FGLDS1; MODED; MPAPA; MYCNsORF; MYCNsPEP; N-myc; NMYC; ODED; bHLHe37; Nmyc-1; Nmyc1; c-nmyc; Nmuc1; MYCN_HUMAN; MYCN; Class E basic helix-loop-helix protein 37 (bHLHe37); MYCN_MOUSE; MYCN_RAT; MYCN proto-oncogene, bHLH transcription factor; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:400-800,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYCN |
|---|---|
| Synonyms | BHLHE37, NMYC |
| Function | Positively regulates the transcription of MYCNOS in neuroblastoma cells. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99776
