|Application ||WB, IHC-P, FC, E|
|Other Accession||Q925G0, O89086|
|Calculated MW||17170 Da|
|Other Names||Putative RNA-binding protein 3, RNA-binding motif protein 3, RNPL, RBM3, RNPL|
|Target/Specificity||This RBM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the C-terminal region of human RBM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cell projection, dendrite Note=Localizes in mRNA granules in dentrites.|
Provided below are standard protocols that you may find useful for product applications.
RBM3 is a member of the glycine-rich RNA-binding protein family and a protein with one RNA recognition motif (RRM) domain. Expression of this protein is induced by cold shock and low oxygen tension.
Zeng,Y., J. Cell. Biochem. 107 (1), 179-188 (2009)
Sureban,S.M., Oncogene 27 (33), 4544-4556 (2008)