Metabotropic Glutamate Receptor 2 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q14416
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	95568 Da

Protein Information
Name	GRM2 (HGNC:4594)
Synonyms	GPRC1B, MGLUR2
Function	Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Cellular Location	Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite
Tissue Location	Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.