癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Sestrin-1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y6P5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56557 Da |
| Antigen Region | 14-43 aa |
| Gene ID | 27244 |
|---|---|
| Other Names | Sestrin-1, p53-regulated protein PA26, SESN1, PA26, SEST1 |
| Target/Specificity | This Sestrin-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human Sestrin-1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Sestrin-1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SESN1 (HGNC:21595) |
|---|---|
| Function | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Widely expressed.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sestrin-1 is involved in the reduction of peroxiredoxins. This protein may also be regulator of cellular growth.
REFERENCES
Budanov,A.V., Science 304 (5670), 596-600 (2004) Peeters,H., Hum. Genet. 112 (5-6), 573-580 (2003) Velasco-Miguel,S., Oncogene 18 (1), 127-137 (1999)
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