Moesin Rabbit mAb

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IHC-F, IP, ICC
Primary Accession	P26038
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	67820 Da

Additional Information
Gene ID	4478
Other Names	MSN
Dilution	WB~~1/500-1/1000 IHC-P~~N/A IHC-F~~N/A IP~~1/20 ICC~~N/A
Format	Liquid

Protein Information
Name	MSN (HGNC:7373)
Function	Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666).
Cellular Location	Cell membrane; Peripheral membrane protein {ECO:0000250\|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250\|UniProtKB:P26041}. Cytoplasm, cytoskeleton {ECO:0000250\|UniProtKB:P26041}. Apical cell membrane {ECO:0000250\|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250\|UniProtKB:P26041}. Cell projection, microvillus membrane {ECO:0000250\|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250\|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250\|UniProtKB:P26041}. Cell projection, microvillus {ECO:0000250\|UniProtKB:P26041}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. {ECO:0000250\|UniProtKB:P26041, ECO:0000269\|PubMed:18586956, ECO:0000269\|PubMed:9298994}
Tissue Location	In all tissues and cultured cells studied.