QSOX1 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IP
Primary Accession	O00391
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	82578 Da

Protein Information
Name	QSOX1
Synonyms	QSCN6 {ECO:0000303\|PubMed:9878249}
Function	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560).
Cellular Location	[Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor
Tissue Location	Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney {ECO:0000269\|PubMed:10708601, ECO:0000269\|Ref.8}