SEC24D Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	O94855
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	113010 Da

Additional Information
Gene ID	9871
Other Names	SEC24D
Dilution	WB~~1/500-1/1000
Format	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Protein Information
Name	SEC24D (HGNC:10706)
Function	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
Cellular Location	Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein {ECO:0000250\|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250\|UniProtKB:P53992}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250\|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250\|UniProtKB:P53992}. Cytoplasm, cytosol {ECO:0000250\|UniProtKB:P53992}
Tissue Location	Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.