Superoxide Dismutase 3 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	P08294
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal Antibody
Isotype	IgG
Conjugate	Unconjugated
Immunogen	A synthesized peptide derived from human Superoxide Dismutase 3
Purification	Affinity Chromatography
Calculated MW	25851 Da

Additional Information
Gene ID	6649
Other Names	SOD3
Dilution	WB~~1/500-1/1000 IHC-P~~1:50~200
Format	Liquid in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	SOD3 (HGNC:11181)
Function	Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage (PubMed:12933702, PubMed:15761197). Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite (PubMed:12933702). Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators (PubMed:31326693).
Cellular Location	Secreted, extracellular space. Golgi apparatus, trans-Golgi network {ECO:0000250\|UniProtKB:O09164}. Vesicle Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium (PubMed:8546689). In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles (PubMed:31326693)
Tissue Location	Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid (PubMed:7959763). Stored in macrophages intracellular compartments (PubMed:31326693)