MSR1 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	P21757
Reactivity	Rat, Human, Mouse
Host	Rabbit
Clonality	Monoclonal Antibody
Isotype	IgG
Conjugate	Unconjugated
Immunogen	A synthesized peptide derived from human MSR1
Purification	Affinity Chromatography
Calculated MW	49762 Da

Additional Information
Gene ID	4481
Other Names	MSR1
Dilution	WB~~1/500-1/1000
Format	Liquid in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	MSR1
Synonyms	SCARA1
Function	Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis (PubMed:2251254, PubMed:34252459). Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense (PubMed:10722588). Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling (PubMed:29057947, PubMed:40980882).
Cellular Location	Cell membrane; Single-pass type II membrane protein
Tissue Location	Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.