PD-L1
- 产品详情
- 实验流程
Application ![]()
| IHC-P, E |
---|---|
Primary Accession | Q9NZQ7 |
Reactivity | Human |
Host | Rabbit |
Clonality | monoclonal |
Isotype | Rabbit IgG |
Calculated MW | 33275 Da |
Gene ID | 29126 |
---|---|
Target/Specificity | Recombinant anti-PD-L1 monoclonal antibody recognizes endogenous levels of total PD-L1 protein. |
Dilution | IHC-P~~N/A E~~Use at an assay dependent concentration. |
Format | Purified recombination monoclonal antibody supplied in PBS with 0.05% (W/V) Proclin300, and 0.05% BSA. This antibody is purified through a protein A column. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PD-L1 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD274 (HGNC:17635) |
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Function | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Nucleus. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). [Isoform 2]: Endomembrane system; Single-pass type I membrane protein |
Tissue Location | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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