癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ICAM1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P05362 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57825 Da |
| Antigen Region | 488-514 aa |
| Gene ID | 3383 |
|---|---|
| Other Names | Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1 |
| Target/Specificity | This ICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 488-514 amino acids from the C-terminal region of human ICAM1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ICAM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ICAM1 |
|---|---|
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ICAM1 is a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
REFERENCES
Denkers,I.A., et.al., Leuk. Res. 16 (5), 469-474 (1992)
Rossler,K., et.al., J. Neurosci. Res. 31 (2), 365-374 (1992)
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Discontinued
Cat# AP8656b
Size:
50 µl
100 µl
200 µl
400 µl
Price:
¥ 1,100.00
¥ 1,800.00
¥ 2,600.00
¥ 4,000.00
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