癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RPGRIP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q96KN7 |
| Other Accession | NP_065099 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 146682 Da |
| Antigen Region | 530-557 aa |
| Gene ID | 57096 |
|---|---|
| Other Names | X-linked retinitis pigmentosa GTPase regulator-interacting protein 1, RPGR-interacting protein 1, RPGRIP1 |
| Target/Specificity | This RPGRIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-557 amino acids from the Central region of human RPGRIP1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RPGRIP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPGRIP1 |
|---|---|
| Function | May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. |
| Cellular Location | Cell projection, cilium. Note=Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity). {ECO:0000250|UniProtKB:Q9EPQ2} |
| Tissue Location | Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RPGRIP1 is a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells.
REFERENCES
Arts,H.H.,et.al., Nat. Genet. 39 (7), 882-888 (2007)
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