癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-2019-nCoV Nucleoprotein (N)-C-term
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, EWB, IHC-P, E |
|---|---|
| Primary Accession | P0DTC9 |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45626 Da |
| Gene ID | 43740575 |
|---|---|
| Other Names | N nucleocapsid phosphoprotein, YP_009724397.2 |
| Dilution | WB~~1:1000 IHC-P~~N/A E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-2019-nCoV Nucleoprotein (N)-C-term is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | N {ECO:0000255|HAMAP-Rule:MF_04096} |
|---|---|
| Function | Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M (PubMed:33264373). Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions (PubMed:34901782, PubMed:36534661). |
| Cellular Location | Virion {ECO:0000255|HAMAP-Rule:MF_04096}. Host cytoplasm Secreted. Host extracellular space. Note=Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. When located inside the virion, complexed with the viral RNA Can be secreted by unconventional protein secretion (UPS) (PubMed:35921414). When secreted, can bind to host glycosaminoglycans on infected and non infected cells (PubMed:35921414). Found in host cytoplasmic stress granules (PubMed:34901782). {ECO:0000255|HAMAP- Rule:MF_04096, ECO:0000269|PubMed:34901782, ECO:0000269|PubMed:35921414} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
