癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SARS-CoV-2 (2019-nCoV) Nucleocapsid, WT & Ormicron Recognized Mouse mAb
SARS-CoV-2 (2019-nCoV) Nucleocapsid, WT & Ormicron Recognized Mouse mAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P0DTC9 |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 45626 Da |
| Physical State | Liquid |
| Immunogen | Recombinant SARS-CoV-2 Nucleocapsid Protein |
| Epitope Specificity | 1-419/419 |
| Isotype | IgG1 |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M PBS (pH7.4). |
| SUBCELLULAR LOCATION | Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct. |
| Gene ID | 43740575 |
|---|---|
| Other Names | Nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04096}, N, Nucleocapsid protein {ECO:0000255|HAMAP-Rule:MF_04096}, NC {ECO:0000255|HAMAP-Rule:MF_04096}, Protein N {ECO:0000255|HAMAP-Rule:MF_04096}, N {ECO:0000255|HAMAP-Rule:MF_04096} |
| Dilution | WB=1:500-2000,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | N {ECO:0000255|HAMAP-Rule:MF_04096} |
|---|---|
| Function | Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M (PubMed:33264373). Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions (PubMed:34901782, PubMed:36534661). |
| Cellular Location | Virion {ECO:0000255|HAMAP-Rule:MF_04096}. Host cytoplasm. Secreted Host extracellular space. Note=Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. When located inside the virion, complexed with the viral RNA. Can be secreted by unconventional protein secretion (UPS) (PubMed:35921414). When secreted, can bind to host glycosaminoglycans on infected and non infected cells (PubMed:35921414). Found in host cytoplasmic stress granules (PubMed:34901782). {ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:34901782, ECO:0000269|PubMed:35921414} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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¥ 1,250.00
Cat# AP94732
