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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   Myosin Light Chain 2 Antibody   

Myosin Light Chain 2 Antibody

Rabbit mAb

     
  • 0 - Myosin Light Chain 2 Antibody AP90711
    Western blot analysis of Myosin Light Chain 2 expression in Mouse heart lysate.
  • 0 - Myosin Light Chain 2 Antibody AP90711
    Immunohistochemical analysis of paraffin-embedded human heart, using Myosin Light Chain 2 Antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IP
Primary Accession P10916
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names MYL2; MLC2; Myosin light chain 2; MLC-2; RLC of myosin; CMH10; MLC-2v;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 18789 Da
Additional Information
Dilution WB 1:1000~1:5000 IHC 1:50~1:200 IP 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human Myosin Light Chain 2
Description Myosin is composed of six polypeptide chains: two identical heavy chains and two pairs of light chains. Myosin light chain 2 (MLC2), also known as myosin regulatory light chain (MRLC), RLC, or LC20, has many isoforms depending on its distribution. In smooth muscle, MLC2 is phosphorylated at Thr18 and Ser19 by myosin light chain kinase (MLCK) in a Ca2+/calmodulin-dependent manner.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name MYL2 (HGNC:7583)
Function Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
Cellular Location Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}
Tissue Location Highly expressed in type I muscle fibers.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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