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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   Neutrophil Elastase Antibody   

Neutrophil Elastase Antibody

Rabbit mAb

     
  • 0 - Neutrophil Elastase Antibody AP91077
    Western blot analysis of Neutrophil Elastase expression in HL60 cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, FC, ICC, IHF
Primary Accession P08246
Reactivity Human, Mouse
Clonality Monoclonal
Other Names ELA2; ELANE; Elastase 2; Medullasin; Neutrophil elastase; PMN E; SCN1;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 28518 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:100~1:500 ICC/IF 1:50~1:200 FC 1:30
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human Neutrophil Elastase
Description Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name ELANE
Synonyms ELA2
Function Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed:9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed:20676107, PubMed:25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984).
Cellular Location Cytoplasmic vesicle, phagosome. Note=Localized in phagolysosomes following ingestion of E.coli by neutrophils
Tissue Location Bone marrow cells. Neutrophil (PubMed:10947984).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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