Neutrophil Elastase Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IHC, IF, FC, ICC, IHF |
---|---|
Primary Accession | P08246 |
Reactivity | Human, Mouse |
Clonality | Monoclonal |
Other Names | ELA2; ELANE; Elastase 2; Medullasin; Neutrophil elastase; PMN E; SCN1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 28518 Da |
Dilution | WB 1:500~1:2000 IHC 1:100~1:500 ICC/IF 1:50~1:200 FC 1:30 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human Neutrophil Elastase |
Description | Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | ELANE |
---|---|
Synonyms | ELA2 |
Function | Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed:9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed:20676107, PubMed:25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). |
Cellular Location | Cytoplasmic vesicle, phagosome. Note=Localized in phagolysosomes following ingestion of E.coli by neutrophils |
Tissue Location | Bone marrow cells. Neutrophil (PubMed:10947984). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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