Claudin 4 Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IHC, IP |
---|---|
Primary Accession | O14493 |
Reactivity | Human |
Clonality | Monoclonal |
Other Names | CLD4; CLDN4; CPE- receptor; CPE-R; CPER; CPETR1; Clostridium perfringens enterotoxin receptor; WBSCR8; Williams-Beuren syndrome chromosome region 8 protein; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 22077 Da |
Dilution | WB 1:500~1:1000 IHC 1:100~1:500 IP 1:20 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human Claudin 4 |
Description | Plays a major role in tight junction-specific obliteration of the intercellular space. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | CLDN4 {ECO:0000303|PubMed:35773259, ECO:0000312|HGNC:HGNC:2046} |
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Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed:35773259, PubMed:36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed:35773259, PubMed:36008380). Cannot form tight junction strands on its own (PubMed:35773259, PubMed:36008380). |
Cellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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