CRYAA Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IF, ICC |
---|---|
Primary Accession | P02489 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Other Names | Acry 1; CRYA1; CRYAA; HspB4; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 19909 Da |
Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human CRYAA |
Description | May contribute to the transparency and refractive index of the lens. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | CRYAA |
---|---|
Synonyms | CRYA1, HSPB4 |
Function | Contributes to the transparency and refractive index of the lens (PubMed:18302245). In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:18199971, PubMed:19595763, PubMed:22120592, PubMed:31792453). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). |
Cellular Location | Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles |
Tissue Location | Expressed in the eye lens (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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