癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DBC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O60477 |
| Other Accession | Q925T8, Q920P3, Q7ZZR3, Q5E9L2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 88760 Da |
| Antigen Region | 85-111 aa |
| Gene ID | 1620 |
|---|---|
| Other Names | BMP/retinoic acid-inducible neural-specific protein 1, Deleted in bladder cancer protein 1, BRINP1, DBC1, DBCCR1, FAM5A |
| Target/Specificity | This DBC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the N-terminal region of human DBC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DBC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BRINP1 |
|---|---|
| Synonyms | DBC1, DBCCR1, FAM5A |
| Function | Plays a role in neurogenesis and brain development (By similarity). May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:11420708). |
| Cellular Location | Cytoplasm |
| Tissue Location | Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.
REFERENCES
Koyama, S., et al. Biochem. Biophys. Res. Commun. 392(3):357-362(2010)
Gronbaek, K., et al. Mod. Pathol. 21(5):632-638(2008)
Louhelainen, J.P., et al. Oncogene 25(16):2409-2419(2006)
Izumi, H., et al. Hum. Mol. Genet. 14(8):997-1007(2005)
Beetz, C., et al. Oncol. Rep. 13(2):335-340(2005)
Nishiyama, H., et al. Oncogene 20(23):2956-2964(2001)
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