癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NOXA1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86UR1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50933 Da |
| Antigen Region | 449-478 aa |
| Gene ID | 10811 |
|---|---|
| Other Names | NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox, NOXA1, P51NOX |
| Target/Specificity | This NOXA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-478 amino acids from the C-terminal region of human NOXA1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOXA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOXA1 |
|---|---|
| Synonyms | P51NOX |
| Function | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1 |
| Tissue Location | Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). The NOX activator NOXA1 can stimulate both NOX1 (MIM 300225) and NOX2 (CYBB; MIM 300481), but it appears to be more effective in activating NOX1 (Opitz et al., 2007 [PubMed 17189823]).[supplied by OMIM].
REFERENCES
?Niu, X.L., et al. Circulation 121(4):549-559(2010)
?Pacquelet, S., et al. J. Biol. Chem. 283(36):24649-24658(2008)
?Honjo, T., et al. Endothelium 15(3):137-141(2008)
?Kim, J.S., et al. J. Biol. Chem. 282(48):34787-34800(2007)
?Valente, A.J., et al. Free Radic. Biol. Med. 43(3):384-396(2007)
?Cheng, G., et al. J. Biol. Chem. 281(26):17718-17726(2006)
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