癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-OTUD4 Antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q01804 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 124045 Da |
| Gene ID | 54726 |
|---|---|
| Other Names | HIN1; KIAA1046; OTU domain-containing protein 4; HIV-1-induced protein HIN-1 |
| Target/Specificity | Recombinant fusion protein of human OTUD4 expressed in E. Coli |
| Dilution | WB~~WB (1/500 - 1/1000) FC~~FC (1/100 - 1/200) |
| Format | Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OTUD4 (HGNC:24949) |
|---|---|
| Function | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). |
| Cellular Location | Cytoplasm. Nucleus. Note=Primarily cytoplasmic |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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