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stabilin1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NY15 |
| Other Accession | Q9NY15 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 275482 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human stabilin1 |
| Epitope Specificity | 1201-1400/2570 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 16 EGF-like domains. Contains 7 FAS1 domains. Contains 2 laminin EGF-like domains. Contains 1 Link domain. |
| SUBUNIT | Interacts with CHID1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. |
| Gene ID | 23166 |
|---|---|
| Other Names | CLEVER-1; FEEL-1; FEEL1; FELE-1; FEX1; HRFT; SCARH2; STAB-1; STAB1_HUMAN; STAB1; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1 (FEEL-1); MS-1 antigen; KIAA0246; stabilin 1; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1; common lymphatic endothelial and vascular endothelial receptor-1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STAB1 |
|---|---|
| Synonyms | FEEL1, KIAA0246 |
| Function | Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96237
