癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VEGFA Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q00731 |
| Other Accession | Q00731 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43131 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse VEGF |
| Epitope Specificity | 27-120/232 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the PDGF/VEGF growth factor family. |
| SUBUNIT | Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). |
| DISEASE | Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). |
| Gene ID | 22339 |
|---|---|
| Other Names | L-VEGF; MVCD1; VEGF; VPF; VEGF-A; VEGF111; VEGF164; VEGFA_HUMAN; VEGFA; Vascular permeability factor (VPF); VEGFA_MOUSE; VEGFA_RAT; vascular endothelial growth factor A; vascular endothelial growth factor |
| Dilution | WB=1:500-1000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Vegfa |
|---|---|
| Synonyms | Vegf |
| Function | [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia- mediated cell death (PubMed:35455969). |
| Cellular Location | [N-VEGF]: Cytoplasm {ECO:0000250|UniProtKB:P15692}. Nucleus {ECO:0000250|UniProtKB:P15692} Note=Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions. {ECO:0000250|UniProtKB:P15692} [Isoform L-VEGF-2]: Endoplasmic reticulum {ECO:0000250|UniProtKB:P15692}. Golgi apparatus {ECO:0000250|UniProtKB:P15692}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P15692} [Isoform VEGF-2]: Secreted. |
| Tissue Location | In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression continues in kidney glomeruli and choroid plexus in adults |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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