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KCNAB1/Kv beta 1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q14722 |
| Other Accession | Q14722 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46563 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1 |
| Epitope Specificity | 131-230/419 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the shaker potassium channel beta subunit family. |
| SUBUNIT | Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming å subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus. |
| Gene ID | 7881 |
|---|---|
| Other Names | KCNAB3; KVB1.1; Kvbeta1.1; AKR6A3; KCNA1B; KV-BETA-1; Kvb1.3; hKvBeta3; hKvb3; Akr8a8; mKv(beta)1; KvBeta3; KCAB1_CHICK; KCNAB1; K(+) channel subunit beta-1; 1.1.1.-; KCAB1_BOVIN; KCAB1_HUMAN; KCAB1_MOUSE; Kvb1; KCAB1_RAT; potassium voltage-gated channel subfamily A regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; K+ channel Beta1a chain |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KCNAB1 (HGNC:6228) |
|---|---|
| Synonyms | KCNA1B |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N- terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH- dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down- regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). |
| Cellular Location | Cytoplasm. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. |
| Tissue Location | In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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