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CATSPER Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NEC5 |
| Other Accession | Q8NEC5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90091 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CATSPER |
| Epitope Specificity | 551-650/780 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. |
| SUBUNIT | Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER3 and CATSPER4. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity. |
| DISEASE | Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7) [MIM:612997]. An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CATSPER1 is a voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. It controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. It is activated by intracellular alkalinization. |
| Gene ID | 117144 |
|---|---|
| Other Names | CATSPER; SPGF7; KSper; CTSR1_HUMAN; CATSPER1; hCatSper; CTSR1_MOUSE; cation channel sperm associated 1; cation channel, sperm associated 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CATSPER1 |
|---|---|
| Function | Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium- dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. |
| Cellular Location | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZR5}. Note=Specifically located in the principal piece of the sperm tail. |
| Tissue Location | Testis-specific. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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