癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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C1GALT1C1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96EU7 |
| Other Accession | Q96EU7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36382 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C1GALT1C1 |
| Epitope Specificity | 181-280/318 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. |
| SUBUNIT | Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form. |
| DISEASE | Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN) [MIM:300622]. Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009] |
| Gene ID | 29071 |
|---|---|
| Other Names | AHUS8; C1GALT2; C38H2-L1; COSMC; HSPC067; MST143; TNPS; C1GLC_HUMAN; C1GALT1C1; C38H2-like protein 1 (C38H2-L1); Core 1 beta1, 3-galactosyltransferase 2 (C1Gal-T2 | C1GalT2 | Core 1 beta3-Gal-T2); Core 1 beta3-galactosyltransferase-specific molecular chaperone; C1GALT1 specific chaperone 1; core 1 beta3-Gal-T-specific molecular chaperone |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | C1GALT1C1 |
|---|---|
| Synonyms | COSMC |
| Function | Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3- galactosyltransferase (C1GALT1). |
| Cellular Location | Membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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