癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C1GALT1C1 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q96EU7 |
| Other Accession | Q3SX46 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36382 Da |
| Gene ID | 29071 |
|---|---|
| Other Names | C1GALT1-specific chaperone 1, C38H2-like protein 1, C38H2-L1, Core 1 beta1, 3-galactosyltransferase 2, C1Gal-T2, C1GalT2, Core 1 beta3-Gal-T2, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C1GALT1C1, COSMC |
| Target/Specificity | This C1GALT1C1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-60 amino acids from human C1GALT1C1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C1GALT1C1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C1GALT1C1 |
|---|---|
| Synonyms | COSMC |
| Function | Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3- galactosyltransferase (C1GALT1). |
| Cellular Location | Membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
REFERENCES
Kudo T.,et al.J. Biol. Chem. 277:47724-47731(2002).
Kudo T.,et al.J. Biol. Chem. 281:24999-24999(2006).
Ju T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:16613-16618(2002).
Rubboli F.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
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