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GBA2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9HCG7 |
| Other Accession | Q9HCG7 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Chicken, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 104649 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GBA2 |
| Epitope Specificity | 601-700/927 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the non-lysosomal glucosylceramidase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Beta-glucosidase 2, also known as non-lysosomal glucosylceramidase (NLGase), Glucosylceramidase 2, GBA2 or AD035, is a 927 amino acid non-lysosomal glucosylceramidase that catalyzes glucosylceramide into ceramide and free glucose, and is suggested to play a role in carbohydrate transport and metabolism. A single-pass membrane protein, Beta-glucosidase 2 exists as three alternatively spliced isoforms that are widely expressed but found at highest levels in placenta, kidney, brain, skeletal muscle, kidney and heart, with low levels found in liver. Beta-glucosidase 2 activity has been linked to sphingomyelin generation and prevention of glycolipid accumulation. The gene encoding Beta-glucosidase 2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. |
| Gene ID | 57704 |
|---|---|
| Other Names | GBA2_HUMAN; GBA2; NLGase; Beta-glucocerebrosidase 2 (Beta-glucosidase 2); Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Glucosylceramidase 2; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glycosylceramidase; 3.2.1.45; KIAA1605; SPG46; GBA2_MOUSE; glucosylceramidase beta 2; spastic paraplegia 46 (autosomal recessive); glucosidase, beta (bile acid) 2; bile acid beta-glucosidase; non-lysosomal glucosylceramidase; glucocerebrosidase 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GBA2 (HGNC:18986) |
|---|---|
| Function | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl- (1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17105727, PubMed:30308956, PubMed:32144204). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D- glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids (PubMed:11489889, PubMed:17080196, PubMed:9111029). Able to hydrolyze bile acid 3-O- glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:17080196, PubMed:9111029). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N- acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Note=Localization to the plasma membrane and alternative topologies have also been reported |
| Tissue Location | Widely expressed (PubMed:11489889). Mainly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower levels in liver, spleen, small intestine and lung (PubMed:11489889). Detectable in colon, thymus and peripheral blood leukocytes (PubMed:11489889). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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