癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PADI6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6TGC4 |
| Other Accession | Q6TGC4 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77727 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PADI6 |
| Epitope Specificity | 101-200/694 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein arginine deiminase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012] |
| Gene ID | 353238 |
|---|---|
| Other Names | OZEMA16; PREMBL2; hPADVI; PADI6_HUMAN; PADI6; Peptidyl arginine deiminase-like protein; Peptidylarginine deiminase VI (hPADVI); Protein-arginine deiminase type VI; Protein-arginine deiminase type-6; PAD6; peptidyl arginine deiminase 6; peptidyl arginine deiminase, type VI |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PADI6 {ECO:0000303|PubMed:15087120, ECO:0000312|HGNC:HGNC:20449} |
|---|---|
| Function | Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos: they are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to- embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41772195). PADI6 oligomers acts as an essential structural scaffolding element of cytoplasmic lattices (By similarity). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (PubMed:38656308, PubMed:39286527). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). Also nuclear (By similarity) {ECO:0000250|UniProtKB:Q8K3V4, ECO:0000269|PubMed:37922900} |
| Tissue Location | Highly expressed in oocytes and weakly expressed in other somatic tissues. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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